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Dr. Katharina Fucke, Dr. Alison J. Edwards, Dr. Michael R. Probert, Dr. Sarah E. Tallentire, Prof. Judith A. K. Howard and Prof. Jonathan W. Steed Unexpected Low-Temperature Behaviour of Piroxicam Monohydrate ChemPhysChem 14

Version of Record online: 14 JUN 2012 | DOI: 10.1002/cphc.201200316

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Cool runnings: Upon cooling the monohydrate of the anti-inflammatory drug piroxicam shows reversible splitting (see picture). The cell also shows an irregular contraction over temperature and has a memory effect of its thermal history. This is due to strongly hydrogen bonded chains present in the monohydrate, which allow the crystal domains to contract separately from each other.

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