Yangmei Guo and Prof. Dr. Jianping Wang Spectroscopic Evidence for Polymorphic Aggregates Formed by Amyloid-β Fragments ChemPhysChem 13
Don't forget the structure: Understanding the structure of amyloid-β aggregates is a key step towards elucidating the pathology of Alzheimer′s disease. The aggregation properties of three fragments of the amyloid β1–42 protein are examined by Fourier transform infrared spectroscopy (see picture). The structures of the formed aggregates are found to be both sequence and pH dependent. Detailed structural differences, particularly with regard to parallel and antiparallel β-sheets, are observed.
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