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M. Škodová, Dr. P. Černoch, Dr. P. Štěpánek, Dr. E. Chánová, Dr. J. Kučka, Z. Kálalová, D. Kaňková and Dr. M. Hrubý Self-Assembled Polymeric Chelate Nanoparticles as Potential Theranostic Agents ChemPhysChem 13

Article first published online: 6 NOV 2012 | DOI: 10.1002/cphc.201200681

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A graft copolymer containing chelating 8-hydroxyquinoline-5-sulfonic acid moieties on the polymer backbone and hydrophilic poly(ethylene oxide) grafts has been prepared. The copolymer forms spherical nanoparticles with internal porosity by Fe3+-mediated self-assembly, which can be biodegraded by metal transchelation inside cells (see picture).

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