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Dr. Shirin Faraji, Lukas Wirz and Prof. Dr. Andreas Dreuw Quantum Chemical Study of the Enzymatic Repair of T(6-4)C/C(6-4)T UV-Photolesions by DNA Photolyases ChemPhysChem 14

Article first published online: 2 JUL 2013 | DOI: 10.1002/cphc.201300223

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How the fix works: The molecular mechanism of DNA (6-4)-photolyase to repair T(6-4)C and C(6-4)T photoproducts is investigated by means of quantum chemical calculations. Despite the different functional groups of the pyrimidine bases involved in each particular repair process, a general valid molecular mechanism is identified, in which the initial step is an electron transfer coupled to a proton transfer, followed by an intramolecular OH/NH2 transfer step.

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