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Dr. Alfredo González-Pérez and Prof. Juan M. Ruso A Versatile Approach towards the Compaction, Decompaction, and Immobilization of DNA at Interfaces by Using Cyclodextrins ChemPhysChem 14

Version of Record online: 17 MAY 2013 | DOI: 10.1002/cphc.201300234

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Die another DNA: The decompaction of the DNA/hexadecyltrimethylammonium bromide (CTAB) complex is strongly influenced by the concentration of β-cyclodextrin (CD) and by the reaction temperature, owing to a subtle balance between the hydration of the complex and the lower compressibility of the native structures. Moreover, the formation of self-assembled layers of β-CD/CTAB complexes on glass or mica surfaces facilitates the immobilization of DNA, either in its coil or globule conformations (see picture).

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