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Marina Pinheiro, Catarina Pereira-Leite, Mariana Arêde, Dr. Cláudia Nunes, João M. Caio, Dr. Cristina Moiteiro, Dr. Juan J. Giner-Casares , Dr. Marlene Lúcio, Dr. Gerald Brezesinski, Dr. Luis Camacho and Dr. Salette Reis Evaluation of the Structure–Activity Relationship of Rifabutin and Analogs: A Drug–Membrane Study ChemPhysChem 14

Article first published online: 2 JUL 2013 | DOI: 10.1002/cphc.201300262

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Drug–membrane interaction: The interaction of RFB and two novel analogs with a membrane model is studied. Phosphatidylcholines and cholesterol are used to mimic the cell membrane. The obtained results provide information about the relationship between the chemical structure of the antimycobacterial compounds and the changes in the biophysical properties of the membrane, such as its molecular packing.

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