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Prof. Shuchen Hsieh, Chiung-Wen Hsieh, Hsuan-Hung Chou, Chiung-Wen Chang and Ling-Ya Chu Effect of the Surface Chemistry of Insulin Fibrils on the Aggregation Rate ChemPhysChem 15

Article first published online: 2 DEC 2013 | DOI: 10.1002/cphc.201300838

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Structure transition cascade: Insulin fibrils undergo a secondary structural transition—from the α-rich to the β-rich form—upon progressively increasing the incubation time from 0.5 to ten hours. Atomic force microscopy measurements show that the fibril surface chemistry changes from hydrophilic to hydrophobic and the aggregation rate increases fivefold.

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