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Dr. Nikola Ž. Knežević, Dr. Igor I. Slowing and Dr. Victor S.-Y. Lin Tuning the Release of Anticancer Drugs from Magnetic Iron Oxide/Mesoporous Silica Core/Shell Nanoparticles ChemPlusChem 77

Article first published online: 16 DEC 2011 | DOI: 10.1002/cplu.201100026

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A series of core/shell magnetic mesoporous silica nanoparticle (MMSN) materials were prepared. The loading and release of anticancer drugs, 9-aminoacridine (9AA) and camptothecin (CPT), as well as cytotoxic activity of drug loaded materials, is influenced by the presence of phenylethyl functionalization inside the MMSN mesopores (see figure). An externally applied magnetic field accelerates the drug release from the materials.

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