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Dmitrii S. Bolotin, Dr. Nadezhda A. Bokach, Prof. Dr. Matti Haukka and Prof. Dr. Vadim Yu. Kukushkin Platinum(IV)-Mediated Nitrile–Amidoxime Coupling Reactions: Insights into the Mechanism for the Generation of 1,2,4-Oxadiazoles ChemPlusChem 77

Version of Record online: 4 JAN 2012 | DOI: 10.1002/cplu.201100047

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Step by step: The stepwise nucleophilic addition of amidoximes to nitrile ligands in platinum(IV) complexes leads to coordinated O-imidoylamidoximines. These newly formed species after decoordination undergo cyclization (see scheme) to furnish 1,2,4-oxadiazoles. The cyclization is promoted by strong acceptor substituents R′ and is not affected by a metal center.

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