E-mail a Wiley Online Library Link

Dmitrii S. Bolotin, Dr. Nadezhda A. Bokach, Prof. Dr. Matti Haukka and Prof. Dr. Vadim Yu. Kukushkin Platinum(IV)-Mediated Nitrile–Amidoxime Coupling Reactions: Insights into the Mechanism for the Generation of 1,2,4-Oxadiazoles ChemPlusChem 77

Version of Record online: 4 JAN 2012 | DOI: 10.1002/cplu.201100047

Thumbnail image of graphical abstract

Step by step: The stepwise nucleophilic addition of amidoximes to nitrile ligands in platinum(IV) complexes leads to coordinated O-imidoylamidoximines. These newly formed species after decoordination undergo cyclization (see scheme) to furnish 1,2,4-oxadiazoles. The cyclization is promoted by strong acceptor substituents R′ and is not affected by a metal center.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field