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Dr. Qing-Dong Huang, Jiang Ren, Hong Chen, Wen-Jing Ou, Dr. Ji Zhang, Yun Fu, Prof. Dr. Wen Zhu and Prof. Dr. Xiao-Qi Yu Cyclen-Based Cationic Lipids Containing Carbamate Linkages as Efficient Gene Delivery Vectors with Low Toxicity ChemPlusChem 77

Version of Record online: 31 MAY 2012 | DOI: 10.1002/cplu.201200060

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Ready for delivery: Two novel cationic lipids based on protonated cyclen and steroid (cholesterol or diosgenin) moieties with a carbamate linkage have been designed and synthesized for gene delivery. The gene transfection efficiency of two cationic lipids were found to be higher than that of commercially available Lipofectamine 2000. The lipoplexes formed from both cationic lipids were found to have low cytotoxicity in three cell lines even at high N/P ratios (see plot for H460 cells).

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