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Dr. Kirti Dhingra Verma, Dr. Anurag Mishra, Dr. Jörn Engelmann, Michael Beyerlein, Prof. Dr. Martin E. Maier and Prof. Dr. Nikos K. Logothetis Magnetic-Field-Dependent 1H Relaxivity Behavior of Biotin/Avidin-Based Magnetic Resonance Imaging Probes ChemPlusChem 77

Article first published online: 25 JUN 2012 | DOI: 10.1002/cplu.201200064

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High relaxivity contrast agents for targeted MRI: Two biotinylated contrast agents (CAs), [Gd.L1–2], have been synthesized and characterized for magnetic resonance imaging (see figure). On binding to avidin, the transverse proton relaxivity (r2p) of [Gd.L1] undergoes a 906 % increase compared with 225 % for [Gd.L2]. The longitudinal proton relaxivity (r1p) shows strong field dependence. [Gd.L1]–avidin allows access of two H2O molecules to Gd whereas [Gd.L2]–avidin allows one.

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