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Dr. Edith Chardon, Dr. Gian Luigi Puleo, Georges Dahm, Prof. Sylvie Fournel, Dr. Gilles Guichard and Dr. Stéphane Bellemin-Laponnaz Easy Derivatisation of Group 10 N-Heterocyclic Carbene Complexes and In Vitro Evaluation of an Anticancer Oestradiol Conjugate ChemPlusChem 77

Version of Record online: 27 SEP 2012 | DOI: 10.1002/cplu.201200092

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Right on target! Ruthenium-catalysed 1,3-dipolar cycloaddition has been used to functionalise a series of Pd and Pt N-heterocyclic carbene (NHC) complexes (see scheme). This strategy was applied to the conjugation of amino acid, polyethylene glycol and oestradiol derivatives. These results bode well for the development of Pt–NHC complexes functionalised with cell-targeting elements.

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