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Dr. Pascal Rouge, Dr. Alexandra Dassonville-Klimpt, Dr. Christine Cézard, Dr. Stéphanie Boudesocque, Dr. Roger Ourouda, Dr. Carole Amant, Dr. François Gaboriau, Dr. Isabelle Forfar, Prof. Dr. Jean Guillon, Prof. Dr. Emmanuel Guillon, Dr. Enguerran Vanquelef, Dr. Piotr Cieplak, Prof. Dr. François-Yves Dupradeau, Prof. Dr. Laurent Dupont and Prof. Dr. Pascal Sonnet Synthesis, Physicochemical Studies, Molecular Dynamics Simulations, and Metal-Ion-Dependent Antiproliferative and Antiangiogenic Properties of Cone ICL670-Substituted Calix[4]arenes ChemPlusChem 77

Version of Record online: 23 SEP 2012 | DOI: 10.1002/cplu.201200141

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Let′s stick together: A series of calix[4]arenes substituted at the lower rim with ICL670, a strong FeIII chelator (see figure), has been synthesized. This grafting improved the iron-chelating and lipophilicity properties of the calixarenes and their antiproliferative and antiangiogenic properties were investigated.

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