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Dr. Giorgia Botta, Dr. Michela Delfino, Dr. Melissa Guazzaroni, Dr. Claudia Crestini, Prof. Dr. Silvano Onofri and Prof. Dr. Raffaele Saladino Selective Synthesis of DOPA and DOPA Peptides by Native and Immobilized Tyrosinase in Organic Solvent ChemPlusChem 78

Version of Record online: 21 FEB 2013 | DOI: 10.1002/cplu.201200300

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A direct route: Bioactive catechol derivatives, such as Boc-Gly-DOPA-OMe (Boc=tert-butoxycarbonyl, DOPA=3,4-dihydroxyphenylalanine), have been synthesized from the corresponding L-tyrosine (Tyr) derivatives (see scheme). The oxidation is performed with immobilized tyrosinase, from Agaricus bisporus, in CH2Cl2/buffer at room temperature under an O2 atmosphere.

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