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Dr. Sascha N. Goonewardena, Dr. Hong Zong, Dr. Pascale R. Leroueil and Prof. James R. Baker Jr. Bioorthogonal Chemical Handle for Tracking Multifunctional Nanoparticles ChemPlusChem 78

Version of Record online: 3 APR 2013 | DOI: 10.1002/cplu.201300007

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Getting a handle on it: An innovative strategy for tracking multifunctional nanoparticles in biological systems is presented that simplifies the syntheses and can be used to track the nanoparticles in vitro and in vivo. The strategy is based on in situ click chemistry ligation of fluorescent reporters to the nanoparticle scaffold through copper-catalyzed azide–alkyne cycloaddition (see figure).

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