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Voislav Blagojevic and Diethard K. Bohme Trimethylation and Differential Mobility Spectroscopy in Quantitative Peptide Analysis: Increasing Selectivity and Sensitivity through Ion/Molecule Chemistry ChemPlusChem 78

Version of Record online: 1 JUL 2013 | DOI: 10.1002/cplu.201300126

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Be selective: Combination of peptide trimethylation isotopic labeling and chemically enhanced differential mobility spectroscopy (DMS) provides a significant increase in selectivity and sensitivity of quantitative peptide analysis. This is achieved through suppression of protonated ions by induced proton transfer to the DMS modifier, leaving the quaternary amine of the trimethylated ions unaffected (HG=hexaglycine, TMEHG=trimethylated esterified hexaglycine).

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