E-mail a Wiley Online Library Link

Yukina Mizuta, Prof. Akinori Takasu and Masahiro Higuchi Synthesis of Cell-Penetrating S-Galactosyl–Oligoarginine Peptides as Inducers of Recombinant Protein Expression under the Control of lac Operator/Repressor Systems ChemPlusChem 78

Article first published online: 23 MAY 2013 | DOI: 10.1002/cplu.201300130

Thumbnail image of graphical abstract

Just passing through: S-galactosyl–oligo(Arg) conjugates (see scheme) as new inducers for protein biosynthesis in bacteria have been synthesized. In vivo expression of green fluorescence protein (GFP) was induced by S-Gal–(Arg)n at the T5 promoter in E. coli. The level of GFP expression was directly related to the number of arginine moieties in each peptide, which are proposed to be responsible for how well each peptide passes through the E. coli membrane.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field