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Xin Yan, Dr. Rodinei Augusti, Dr. Xin Li and Dr. R. Graham Cooks Chemical Reactivity Assessment Using Reactive Paper Spray Ionization Mass Spectrometry: The Katritzky Reaction ChemPlusChem 78

Article first published online: 5 AUG 2013 | DOI: 10.1002/cplu.201300172

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Paper screening: The reactive paper spray technique allows organic reactions to be performed rapidly in solution under ambient conditions. On coupling to mass spectrometry (MS; see figure for the Katritzky reaction), it comprises a new platform technology that is useful to assess organic reactivity. This approach allows efficient reaction optimization and activity screening as well as rapid product detection/characterization.

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