Gaëlle Bœuf, Gaëlle V. Roullin, Dr. Juliette Moreau, Laurence Van Gulick, Dr. Nebraska Zambrano Pineda, Dr. Christine Terryn, Prof. Dominique Ploton, Prof. Marie Christine Andry, Prof. Françoise Chuburu, Dr. Sylvain Dukic, Prof. Michaël Molinari and Prof. Gilles Lemercier Encapsulated Ruthenium(II) Complexes in Biocompatible Poly(d,l-lactide-co-glycolide) Nanoparticles for Application in Photodynamic Therapy ChemPlusChem 79
Article first published online: 7 JAN 2014 | DOI: 10.1002/cplu.201300242
Leading light: Encapsulation and confinement of ruthenium complexes in biocompatible poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles has been performed. The Ru complex@PLGA nanosuspensions are stable. Once gathered in tumor tissues, irradiation would autoaccelerate the release and hence the toxicity of the Ru complex (see figure), thus making these nanoparticles candidates for photodynamic therapy (PDT) and two-photon excited PDT.
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