Sumit B. Kamble, Rameshwar K. Swami, Sachin S. Sakate and Dr. Chandrashekhar V. Rode Highly Efficient Povidone–Phosphotungstic Acid Catalyst for the Tandem Acetalization of Aldehydes to Bis- and Tris(indolyl)methanes ChemPlusChem 78
One after the other: A hybrid of heteropoly acid and polyvinylpyrrolidone (povidone) catalyzes the acetalization of aldehydes in methanol at room temperature followed by reaction with indole to give bis- and tris(indolyl)methanes. The reaction proceeds through the acetal as an intermediate and not through the azafulvene (see scheme). The catalyst can be recycled efficiently.
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