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Mayuri Napagoda, Dr. Lubomír Rulíšek, Andrej Jančařík, Jiří Klívar, Michal Šámal, Dr. Irena G. Stará, Dr. Ivo Starý, Dr. Veronika Šolínová, Dr. Václav Kašička and Dr. Aleš Svatoš Azahelicene Superbases as MAILD Matrices for Acidic Analytes ChemPlusChem 78

Version of Record online: 19 AUG 2013 | DOI: 10.1002/cplu.201300258

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Fitting the profile: A superbasic 1,14-diaza[5]helicene can serve as an efficient, ionless matrix for matrix-assisted ionization/laser desorption (MAILD) spectrometry. The matrix outperforms other bases by acting as a kinetically active proton sponge and is highly suitable for high-throughput metabolomics analysis. There is a correlation between the basicity (and proton-sponge character) of matrices and their efficacy in MAILD-MS.

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