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Takuya Kamiyama, Merve Sinem Özer, Elisabeth Otth, Dr. Jan Deska and Dr. Ján Cvengroš Modular Synthesis of Optically Active Tröger’s Base Analogues ChemPlusChem 78

Version of Record online: 5 SEP 2013 | DOI: 10.1002/cplu.201300295

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Tipping the scales: For the first time, enantioselective catalysis was applied for the preparation of Tröger's base derivatives affording N-stereogenic building blocks not only in excellent enantiomeric purity but also in an easily scalable fashion (see scheme). Enzymatic kinetic resolution proved efficient to yield functionalized Tröger's bases, which can be subsequently modified by various chemical methods without any erosion of stereogenic information.

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