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Dr. Gajendra Gupta, Dr. Jerald Mahesh Kumar, Amine Garci, Nandini Rangaraj, Dr. Narayana Nagesh and Prof. Dr. Bruno Therrien Anticancer Activity of Half-Sandwich RhIII and IrIII Metalla-Prisms Containing Lipophilic Side Chains ChemPlusChem 79

Version of Record online: 11 MAR 2014 | DOI: 10.1002/cplu.201300425

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CHARGE! Two hexacationic pentamethylcyclopentadienyl rhodium(III) and iridium(III) metalla-prisms have been synthesized and their antiproliferative activity has been evaluated in vitro in human cancer cell lines. The positively charged metalla-prisms appear to target mitochondria (see figure), and preclinical studies suggest that the rhodium derivative could be a potential antitumor drug.

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