Fen Xu, Chunxiang Wang, Dr. Xincheng Li and Prof. Dr. Boshun Wan Ruthenium-catalyzed [2+2+2] Cycloaddition of Diynes with Nitriles in Pure Water ChemSusChem 5
One ring to bind them: An efficient method for synthesizing highly functionalized pyridine derivatives from diynes and nitriles is described. The reaction system involves Cp*Ru(COD)Cl/tppts-catalyzed [2+2+2] cycloaddition in pure water. Without being accompanied by diyne dimerization or trimerization byproducts, the desired products can be obtained in moderate to high yields.
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