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Dr. Jan-Karl Guterl, Dr. Daniel Garbe, Jörg Carsten, Fabian Steffler, Bettina Sommer, Steven Reiße, Anja Philipp, Martina Haack, Broder Rühmann, Prof. Andre Koltermann, Dr. Ulrich Kettling, Prof. Thomas Brück and Prof. Volker Sieber Cell-Free Metabolic Engineering: Production of Chemicals by Minimized Reaction Cascades ChemSusChem 5

Version of Record online: 19 OCT 2012 | DOI: 10.1002/cssc.201200365

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An order of enzymes, hold the cells: For chemical and fuel production from biomass, chemical methods are often supplemented by biological means, such as microbial systems. It is demonstrated here that microbial reaction cascades can be redesigned and simplified to an extent that cell-free bulk production of chemicals and fuels from biomass becomes feasible. Specifically, glucose is converted to ethanol and to isobutanol by using only six and eight enzymes respectively and one cofactor. Larger alcohols such as isobutanol are known to poison microbial systems.

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