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Dr. Yukihiro Arakawa and Prof. Dr. Helma Wennemers Enamine Catalysis in Flow with an Immobilized Peptidic Catalyst ChemSusChem 6

Version of Record online: 19 NOV 2012 | DOI: 10.1002/cssc.201200740

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Pep talk: An immobilized peptidic catalyst achieves more than 600 turnovers in a continuous-flow system, allowing the production of chiral γ-nitroaldehydes with excellent stereoselectivities on a scale of >450 mmol (>100 g). Such a high efficiency opens the way for more practical applications of enamine catalysis.

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