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Svetlana Borukhova, Dr. Timothy Noël, Bert Metten, Eric de Vos and Prof. Dr. Volker Hessel Solvent- and Catalyst-Free Huisgen Cycloaddition to Rufinamide in Flow with a Greener, Less Expensive Dipolarophile ChemSusChem 6

Article first published online: 23 SEP 2013 | DOI: 10.1002/cssc.201300684

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Give it a flow: A continuous-flow process for the synthesis of a 1,2,3-triazole precursor of Rufinamide has been developed. The protocol involves a solvent- and catalyst-free operation and utilizes reaction temperatures above the melting point of the target product to prevent microreactor clogging, resulting in a decrease of the operating time from hours to minutes.

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