Yasemin Gumrukcu, Prof. Dr. Bas de Bruin and Prof. Dr. Joost N. H. Reek Hydrogen-Bond-Assisted Activation of Allylic Alcohols for Palladium-Catalyzed Coupling Reactions ChemSusChem 7
Hydrogen Bond Rule(s): Direct activation of allylic alcohols and subsequent alkylation and amination reactions are reported. The new catalyst is based on functionalized palladium and phosphoramidite ligands to allow hydrogen bond-assisted activation. Kinetic data are in line with this mechanism as the oxidative addition is the rate-determining step.
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