Dr. George Tsilomelekis, Tyler R. Josephson, Dr. Vladimiros Nikolakis and Dr. Stavros Caratzoulas Origin of 5-Hydroxymethylfurfural Stability in Water/Dimethyl Sulfoxide Mixtures ChemSusChem 7
To HMF with it! 5-Hydroxymethylfurfural (HMF) solvation by DMSO increases its LUMO energy and thus reduces its susceptibility to nucleophilic attack, which minimizes undesirable hydration and humin-formation reactions. DMSO preferentially solvates the HMF carbonyl group over water, which provides an explanation for the enhanced HMF stability in DMSO/water mixtures observed experimentally.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf