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Dr. Vikramaditya G. Yadav and Prof. Gregory Stephanopoulos Metabolic Engineering: The Ultimate Paradigm for Continuous Pharmaceutical Manufacturing ChemSusChem 7

Article first published online: 9 APR 2014 | DOI: 10.1002/cssc.201301219

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The ′pathway′ to a manufacturing renaissance: A new vision for continuous pharmaceutical manufacturing, with metabolic engineering as its engine, is described. This new manufacturing paradigm saliently allows rapid optimization of production variables as well as facile scale-up from gram to ton scales to meet material requirements for clinical trials. These benefits imply that manufacturing can also double up as valuable tool for drug discovery.

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