Natan J. W. Straathof, Hannes P. L. Gemoets, Dr. Xiao Wang, Prof. Dr. Jaap C. Schouten, Prof. Dr. Volker Hessel and Dr. Timothy Noël Rapid Trifluoromethylation and Perfluoroalkylation of Five-Membered Heterocycles by Photoredox Catalysis in Continuous Flow ChemSusChem 7
Photo workflow: A simple and straightforward photocatalytic method for perfluoroalkylation in continuous flow is developed. A photo-microreactor, constructed from commercially available components, enables accelerated photocatalysis employing [Ru(bpy)3Cl2] as photocatalyst under irradiation by blue LED light. A series of electron-rich hetero-aromatics is successfully trifluoromethylated within 8–16 min. Also, a selection of hetero-aromatics is perfluoroalkylated within 10–20 min.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf