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Vincenzo Amodio, Maria Florencia Tevy, Concetta Traina, Tushar Kanti Ghosh and Maria Capovilla Transactivation in Drosophila of human enhancers by human transcription factors involved in congenital heart diseases Developmental Dynamics 241

Version of Record online: 11 OCT 2011 | DOI: 10.1002/dvdy.22763

Key findings:

  • The mammalian transcription factors GATA4, Nkx2.5 and TBX5 are able to transactivate the Nppa and Myh6 human enhancers in Drosophila embryos.

  • The endogenous Drosophila homologs of GATA4, Nkx2.5 and TBX5 are not transactivated by GATA4, Nkx2.5 or TBX5, ruling out a possible endogenous regulatory circuit.

  • Overexpression in the mesoderm of GATA4, Nkx2.5 or TBX5 is lethal and overexpression in eyes and wings causes reduced organs.

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