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Viet Q. Le and Kristi A. Wharton Hyperactive BMP signaling induced by ALK2R206H requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva Developmental Dynamics 241

Article first published online: 15 DEC 2011 | DOI: 10.1002/dvdy.22779

Key findings:

  • FOP mutant ALK2R206H receptor exhibits ligand-independent signaling in Drosophila.

  • Hyperactive ALK2R206H signaling requires BMP type II receptor function.

  • Wild-type ALK2 transduces BMP7-induced signaling but inhibits signaling by Gbb, Dpp, and hBMP4.

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