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David Terrell, Baotong Xie, Michael Workman, Simpla Mahato, Andrew Zelhof, Brian Gebelein and Tiffany Cook OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye Developmental Dynamics 241

Article first published online: 23 NOV 2011 | DOI: 10.1002/dvdy.22782

Key findings:

  • Human OTX factors—OTX1, OTX2 and CRX—perform overlapping, yet distinct subsets of Otd-dependent functions during Drosophila eye development, providing a system to study subfunctionalization of a family of related transcription factors.

  • Human OTX factors rescue the morphogenesis of rhabdomeric photoreceptors, suggesting that ciliary and rhabdomeric photoreceptors arose from a common ancestor requiring an Otd-related factor for its development.

  • Different CRX alleles associated with similar retinal degenerations can be functionally distinguished using the fly eye as a model system.

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