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Hunki Paek, Michelle W. Antoine, Frank Diaz and Jean M. Hébert Increased β-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics Developmental Dynamics 241

Article first published online: 18 NOV 2011 | DOI: 10.1002/dvdy.22787

Key findings:

  • Elevating the level of active β-catenin in the anterior neural plate leads to a loss of the telencephalon.

  • Instead, high levels of β-catenin in the anterior neural plate leads to mid-hindbrain characteristics.

  • β-catenin levels may regulate a telencephalic versus mid-hindbrain fate by regulating levels of FGF signaling.

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