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Marianne Deries, André B. Gonçalves, Raquel Vaz, Gabriel G. Martins, Gabriela Rodrigues and Sólveig Thorsteinsdóttir Extracellular matrix remodeling accompanies axial muscle development and morphogenesis in the mouse Developmental Dynamics 241

Article first published online: 29 NOV 2011 | DOI: 10.1002/dvdy.23703

Key findings:

  • Four stages of dermomyotome/myotome development are defined.

  • The interstitial matrix around thde dermomyotome and myotome is rich in fibronectin.

  • Fibronectin and tenascin are enriched at intersegmental borders and penetrate into the myotome.

  • Laminin matrices line the dermomyotome and myotome.

  • These laminin matrices are disassembled as the dermomyotome dissociates and the myotome transforms into the epaxial muscle masses.

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