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Celeste Tríbulo, María Guadalupe Barrionuevo, Tristán H. Agüero, Sara S. Sánchez, Nora B. Calcaterra and Manuel J. Aybar ΔNp63 is regulated by BMP4 signaling and is required for early epidermal development in Xenopus Developmental Dynamics 241

Article first published online: 14 DEC 2011 | DOI: 10.1002/dvdy.23706

Key findings:

  • ΔNp63 expression is regulated by BMP signaling.

  • Gain- and loss-of-function experiments show that ΔNp63 is essential since the earliest steps of epidermis induction for the proper development of this tissue.

  • ΔNp63 participates in epidermal development regulating the expression of some components of the apoptotic pathway.

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