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Margot Williams, Carol Burdsal, Ammasi Periasamy, Mark Lewandoski and Ann Sutherland Mouse primitive streak forms in situ by initiation of epithelial to mesenchymal transition without migration of a cell population Developmental Dynamics 241

Version of Record online: 14 DEC 2011 | DOI: 10.1002/dvdy.23711

Key findings:

  • The posterior epiblast of the murine embryo does not display convergence and extension behavior, coordinated cell migration, or large-scale cell rearrangements prior to or during primitive streak formation.

  • The murine primitive streak develops in situ by initiation of epithelial to mesenchymal transition (EMT) in the posterior-most epiblast, and elongates by anterior progression of this EMT.

  • Loss of basal lamina (BL) precedes other steps of EMT at the primitive streak, and is tightly correlated with the ingression of nascent mesoderm.

  • Cells leave the epiblast and enter the primitive streak by apical constriction and somal translocation.

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