Margot Williams, Carol Burdsal, Ammasi Periasamy, Mark Lewandoski and Ann Sutherland Mouse primitive streak forms in situ by initiation of epithelial to mesenchymal transition without migration of a cell population Developmental Dynamics 241
Version of Record online: 14 DEC 2011 | DOI: 10.1002/dvdy.23711
The posterior epiblast of the murine embryo does not display convergence and extension behavior, coordinated cell migration, or large-scale cell rearrangements prior to or during primitive streak formation.
The murine primitive streak develops in situ by initiation of epithelial to mesenchymal transition (EMT) in the posterior-most epiblast, and elongates by anterior progression of this EMT.
Loss of basal lamina (BL) precedes other steps of EMT at the primitive streak, and is tightly correlated with the ingression of nascent mesoderm.
Cells leave the epiblast and enter the primitive streak by apical constriction and somal translocation.
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