Paola Casini, Irma Nardi and Michela Ori Hyaluronan is required for cranial neural crest cells migration and craniofacial development Developmental Dynamics 241
Article first published online: 19 DEC 2011 | DOI: 10.1002/dvdy.23715
Cranial NCC migrate throughout a hyaluronan rich extracellular matrix
Hyaluronan synthases 1 and 2 activity is necessary to maintain the migratory behaviour of cranial NCC
After NCC migration, the presence of Hyaluronan in the extracellular matrix is necessary for the survival of pre-chondrogenic cranial NCC.
CD44, a Hyaluronan receptor, is required for cranial NCC migration but not for their survival.
In Xenopus, the craniofacial skeleton formation is deeply influenced by the composition of the extracellular matrix during cranial NCC migration and differentiation.
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