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Paola Casini, Irma Nardi and Michela Ori Hyaluronan is required for cranial neural crest cells migration and craniofacial development Developmental Dynamics 241

Article first published online: 19 DEC 2011 | DOI: 10.1002/dvdy.23715

Key findings:

  • Cranial NCC migrate throughout a hyaluronan rich extracellular matrix

  • Hyaluronan synthases 1 and 2 activity is necessary to maintain the migratory behaviour of cranial NCC

  • After NCC migration, the presence of Hyaluronan in the extracellular matrix is necessary for the survival of pre-chondrogenic cranial NCC.

  • CD44, a Hyaluronan receptor, is required for cranial NCC migration but not for their survival.

  • In Xenopus, the craniofacial skeleton formation is deeply influenced by the composition of the extracellular matrix during cranial NCC migration and differentiation.

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