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Marion A. Cooley, Victor M. Fresco, Margaret E. Dorlon, Waleed O. Twal, Nathan V. Lee, Jeremy L. Barth, Christine B. Kern, M. Luisa Iruela-Arispe and W. Scott Argraves Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation Developmental Dynamics 241

Article first published online: 19 DEC 2011 | DOI: 10.1002/dvdy.23716

Key findings:

  • Fibulin-1 promotes ADAMTS1-mediated cleavage of versican.

  • Fibulin-1 deficient embryonic cardiac ventricles have reduced levels of the 70-kDa amino-terminal fragment of versican V1 containing a carboxy terminal DPEAAE sequence.

  • Fibulin-1 deficient embryonic cardiac ventricles have increased trabecular cardiomyocyte proliferation.

  • Fibulin-1 deficient embryonic cardiac ventricles have increased levels of ErbB2 and Erk1/2 activation.

  • Hearts from versicanhdf/hdf embryos lack versican V0/V1 and show a lack of trabeculae.

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