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Hsin-Kai Liao, Ying Wang, Kristin E. Noack Watt, Qin Wen, Justin Breitbach, Chelsy K. Kemmet, Karl J. Clark, Stephen C. Ekker, Jeffrey J. Essner and Maura McGrail Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins Developmental Dynamics 241

Article first published online: 24 JAN 2012 | DOI: 10.1002/dvdy.23725

Key findings:

  • Isolation of appa and aplp2 Tol2 gene trap alleles; appa and aplp2 expression in neuronal tissues during embryogenesis.

  • Secretion of predicted appa-RFP and aplp2-RFP fusion proteins.

  • Accumulation of appa-RFP and aplp2-RFP in living embryos at veinous vasculature.

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