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Zhiyong Liu, Thomas Owen, Jie Fang, R. Sathish Srinivasan and Jian Zuo In vivo notch reactivation in differentiating cochlear hair cells induces sox2 and prox1 expression but does not disrupt hair cell maturation Developmental Dynamics 241

Version of Record online: 21 FEB 2012 | DOI: 10.1002/dvdy.23754

Key findings:

  • Ectopic NICD in neonatal cochlear HCs reactivates Sox2 and Prox1.

  • Ectopic Sox2 is present in both IHCs and OHCs.

  • Ectopic Prox1 is specific to OHCs.

  • Prox1 is primarily expressed in OHCs not IHCs in normal development.

  • HCs mature normally despite ectopic NICD, Sox2 and Prox1 expression.

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