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Roberto Sánchez-Sánchez, Sara L. Morales-Lázaro, José-Manuel Baizabal, Manjula Sunkara, Andrew J. Morris and Diana Escalante-Alcalde Lack of lipid phosphate phosphatase-3 in embryonic stem cells compromises neuronal differentiation and neurite outgrowth Developmental Dynamics 241

Version of Record online: 16 APR 2012 | DOI: 10.1002/dvdy.23779

Key findings:

  • LPP3-deficiency reduces the amount of spinal neural precursors and neurons differentiated from embryonic stem cells.

  • Absence of LPP3 decreases proliferation of neural precursors and increases apoptosis during the neural differentiation of embryoid bodies.

  • Lack of LPP3 expression stimulates the differentiation of smooth muscle actin-expressing cells in ES cells differentiated under neuralizing conditions.

  • Lack of LPP3 produces the accumulation of extracellular dihydro-S1P in embryoid bodies differentiated under neuralizing conditions.

  • Lack of LPP3 in in vitro differentiated spinal neurons affects neurite outgrowth through the activation of Rho and PI3K.

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