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Tomomi Ohmura, Go Shioi, Mariko Hirano and Shinichi Aizawa Neural tube defects by NUAK1 and NUAK2 double mutation Developmental Dynamics 241

Version of Record online: 22 JUN 2012 | DOI: 10.1002/dvdy.23816

Key findings:

  • NUAK1 and NUAK2 double mutants exhibited exencephaly, facial clefting, and spina bifida.

  • In the double mutant cranial neural plate, median hinge point is formed, but dorsolateral hinge points are not apparent.

  • NUAK1 and NUAK2 complementarily function in the apical constriction and apico-basal elongation of the cranial neural plate, which are associated with the dorsolateral hinge point formation.

  • In the double mutant neural plate, phosphorylated myosin light chain 2, F-actin, and cortactin were normally found at the 5-somite stage, but subsequently did not concentrate in apical surfaces, concordant with the inefficient constriction. Acetylated α-tubulin-positive microtubules also began to be formed normally at the 5-somite stage, but subsequently did not develop significantly, concordant with poor elongation.

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