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Yoko Kameda, Takayoshi Saitoh, Noriko Nemoto, Tokio Katoh and Sachiko Iseki Hes1 is required for the development of the superior cervical ganglion of sympathetic trunk and the carotid body Developmental Dynamics 241

Article first published online: 22 JUN 2012 | DOI: 10.1002/dvdy.23819

Key findings:

  • Hes1 gene plays a role in maintaining the undifferentiated cells during development.

  • Hes1 null mutant embryos displayed a severe hypoplasia of the superior cervical ganglion (SCG) of sympathetic trunk.

  • Hes1 null mutants failed to form the common carotid artery as a partially penetrated phenotype (13.3%), resulting in the absence of the carotid body.

  • When the carotid artery was retained, the carotid body of the null mutants was smaller in size than that of wild types.

  • Neural crest derivatives, including the SCG, carotid body, and common carotid artery, were affected by the lack of Hes1.

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