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Ryohei Nagai, Mai Shinomura, Kasane Kishi, Yoshimi Aiyama, Kyoko Harikae, Takeshi Sato, Masami Kanai-Azuma, Masamichi Kurohmaru, Naoki Tsunekawa and Yoshiakira Kanai Dynamics of GFRα1-positive spermatogonia at the early stages of colonization in the recipient testes of W/Wν male mice Developmental Dynamics 241

Version of Record online: 9 JUL 2012 | DOI: 10.1002/dvdy.23824

Key findings:

  • Spermatogenic stem cell (SSC) transplantation assays were used to examine the proliferative patterns and kinetics of donor-derived GFRα1-positive spermatogonia during early colonization.

  • GFRα1-positive cells formed several Aal(aligned)-like spherical cell aggregates within a single spermatogenic patch.

  • The appearance of GFRα1-positive Aal-like aggregates was positively correlated with regional, high-level expression of GDNF, a ligand for GFRα1.

  • These data imply that regional changes in GDNF signal levels may regulate the dynamics of Aal-like GFRα1-positive cell aggregates within each patch, resulting in further selection of survival colonies at later stages.

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