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Sarah Wareing, Alexia Eliades, Georges Lacaud and Valerie Kouskoff ETV2 expression marks blood and endothelium precursors, including hemogenic endothelium, at the onset of blood development Developmental Dynamics 241

Article first published online: 16 JUL 2012 | DOI: 10.1002/dvdy.23825

Key findings:

  • ETV2 expression is tightly associated with the onset of yolk sac hematopoiesis.

  • In vitro and in vivo, ETV2 is expressed not only in FLK1+ cells but also in the TIE2+cKIT+ hemogenic endothelium.

  • ETV2 is absolutely required for the formation of the hemogenic endothelium.

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