Kyeongmi Kim, Blue B. Lake, Tomomi Haremaki, Daniel C. Weinstein and Sergei Y. Sokol Rab11 regulates planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis Developmental Dynamics 241
Article first published online: 16 JUL 2012 | DOI: 10.1002/dvdy.23826
Rab11 is enriched and polarized in multiciliated skin cells and their precursors.
Interference with Rab11 function in ciliated cell precursors causes migration defects and formation of randomly oriented apical domains.
Rab11 is required for the initial polarization of ciliated cell precursors, which is necessary for their intercalation into the superficial ectodermal layer.
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