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A. Flaht, E. Jankowska-Steifer, D.M. Radomska, M. Madej, G. Gula, M. Kujawa and A. Ratajska Cellular phenotypes and spatio-temporal patterns of lymphatic vessel development in embryonic mouse hearts Developmental Dynamics 241

Version of Record online: 19 JUL 2012 | DOI: 10.1002/dvdy.23827

Key findings:

  • The majority of scattered Lyve-1+ cells invading the embryonic heart possess the CD68 or the CD45 marker but not the CD31. A few scattered Lyve-1+ cells exhibit the CD11b or F4/80 antigen but not the CD31.

  • Lyve-1+/CD45+, Lyve-1+/CD68, Lyve-1+/CD11b+, and Lyve-1+/F4/80+ cells can be found in the lymphatic vessel wall (Lyve-1+/Prox-1+) once they have gained the Flk-1 antigen.

  • Apart from entering the embryonic heart via the arterial pole, the lymphatics invade also the venous pole, i.e., atrioventricular sulcus of the dorsal aspect of the heart and the dorsal aspect of the atrial surface.

  • The cellular phenotypes and spatio-temporal pattern of lymphatic primordia differ at the venous pole in comparison with the arterial pole.

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