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Roderick W.C. Scherptong, Monique R.M. Jongbloed, Lambertus J. Wisse, Rebecca Vicente-Steijn, Margot M. Bartelings, Robert E. Poelmann, Martin J. Schalij and Adriana C. Gittenberger-De Groot Morphogenesis of outflow tract rotation during cardiac development: The pulmonary push concept Developmental Dynamics 241

Article first published online: 30 JUL 2012 | DOI: 10.1002/dvdy.23833

Key findings:

  • The addition of Nkx2.5-positive myocardial precursors from the anterior heart field occurs during normal development in an asymmetrical fashion, predominantly below the left branch of the 6th pharyngeal arch artery.

  • The continued addition of right-sided myocardium during normal development results in movement without spiralization of the OFT in which the pulmonary trunk orifice is pushed in a rightward and anterior direction, a mechanism referred to as “pulmonary push.”

  • Deficient or disorganized positioning of the Nkx2.5-positive precursors, as was observed in VEGF120/120 mutants might explain cardiac malformations with side-by-side position of the great arteries, such as double outlet right ventricle.

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