Roderick W.C. Scherptong, Monique R.M. Jongbloed, Lambertus J. Wisse, Rebecca Vicente-Steijn, Margot M. Bartelings, Robert E. Poelmann, Martin J. Schalij and Adriana C. Gittenberger-De Groot Morphogenesis of outflow tract rotation during cardiac development: The pulmonary push concept Developmental Dynamics 241
Article first published online: 30 JUL 2012 | DOI: 10.1002/dvdy.23833
The addition of Nkx2.5-positive myocardial precursors from the anterior heart field occurs during normal development in an asymmetrical fashion, predominantly below the left branch of the 6th pharyngeal arch artery.
The continued addition of right-sided myocardium during normal development results in movement without spiralization of the OFT in which the pulmonary trunk orifice is pushed in a rightward and anterior direction, a mechanism referred to as “pulmonary push.”
Deficient or disorganized positioning of the Nkx2.5-positive precursors, as was observed in VEGF120/120 mutants might explain cardiac malformations with side-by-side position of the great arteries, such as double outlet right ventricle.
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